Lab Phone:(773) 834-2675
B.S., Chemistry, University of Chicago, 1992
Ph.D., Chemistry, California Institute of Technology, 1998
Postdoctoral Fellow, Stanford University
Cells use an extensive toolkit of myosin molecular motors to traffic materials, anchor components, and control their shape. We use a multifaceted approach to understand these incredible molecular machines. Our tools include advanced fluorescence imaging and optical tweezers to watch myosins move in both purified systems and whole cells. We also use structural biology tools to understand how the myosin architecture affects motility. The focus of our groups is to understand how myosins navigate through complex networks of tracks, and how the cytoskeleton is organized through a set of competing molecular interactions. This information will shed light on the dynamic structure of cells, such as at the immune synapse and in cancer cell metastasis.