B.S. Chemistry, University of Science and Technology of China, 1994
Ph.D., Chemistry, Massachusetts Institute of Technology, 2000
Postdoctoral Fellow, Chemical Biology, Harvard University, 2000-2002
Our research program spans a broad range of chemical biology, nucleic acid chemistry and biology, epigenetics, and bioinorganic chemistry. We discovered the first RNA demethylase and continue to explore gene expression regulation mediated by dynamic and reversible RNA modifications. We developed enabling tools to map DNA 5-hydroxymethylcytosine (5hmC) and its oxidation derivatives in mammalian genomes and continue to study DNA 5-methylcytosine (5mC) oxidation and demethylation in biological regulation. We revealed the presence of DNA 6-methyladenosine (6mA) in eukaryotic genomes and continue to investigate functional roles played by this new DNA mark in eukaryotes. We study virulence and antibiotic resistance regulation in human pathogens. We also study metal ion homeostasis and selective metal ion recognition by naturally occurring and engineered proteins.