Structure and biochemistry of proteins involved in immunological recognition. Characterization of nonconventional T cells and their ligands and activating and inhibitory receptors involved in the immune response.
Structural, biochemical and functional studies of adhesion proteins on the cell membrane. Understanding how adhesion-type G-protein-coupled receptors function in the brain.
Regulatory mechanisms controlling bacterial cell physiology and infection biology
Studies sphingolipid signalling pathways and programmed cell death in brain and tumors. Focus on ceramide and the pathways it regulates such as PI3K. Use of quantum dots coated with chaperones as therapy vehicles for inherited lysosomal storage diseases resulting point mutations in Batten genes
Stress-triggered protein self-assembly, cellular stress responses, and molecular evolution.
Steroid hormone regulation of gene networks in reproductive tissues and cancers. Structure and function of nuclear receptors.
Regulation of gene expression by dynamic and reversible RNA modifications, epigenetic DNA methylation in various biological processes and human diseases.
Molecular mechanisms of membrane protein biogenesis and quality control
Chemical protein synthesis. Application of chemistry to the study of proteins. Mechanism of enzyme catalysis.
Structure and function of hormone-receptor interactions, synthetic antibody technology, crystallization chaperones, drug delivery, phage display applications.
Biochemical and cellular mechanisms of actin cytoskeleton assembly, self-organization and maintenance.
Electron magnetic resonance; enzyme mechanisms; metalloenzymes; molecular dynamics; structural basis of enzyme action.
Protein aggregation and amyloid fibril structure; peptide synthesis; lipoprotein structure.
Time-resolved macromolecular crystallography; photoreceptors; design and engineering of light-sensitive proteins
Protein-Protein Interactions in the Extracellular Space and Structural Biology of Protein Receptor/Ligands Involved in Nervous System Development
Non-Coding RNA structure, function, and mechanism; RNA metabolism, engineering antibodies that bind RNA, imaging technology for RNA and cancer
Molecular motors; cytoskeletal organization; single-molecule biophysics
Biophysical studies of the structure, dynamics and function of biological macromolecular systems.
Transcriptional control of ECM expression during chondrogenesis and neurogenesis; regulation of sulfate activation; skeletal dysplasias.
Genome reorganization and multicellular regulatory systems in bacteria populations.
Protein and RNA/ribozyme folding; design of light-sensitive allosteric proteins; structure prediction, biological dynamics and thermodynamics as basis for understanding function.
Membrane cholesterol biochemistry and cellular cholesterol homeostasis.