Structural and Computational Biology
Understanding the molecular underpinnings of biological processes requires an in-depth analysis of the structure and dynamics of proteins, nucleic acids, and the complexes they form. The Department of Biochemistry and Molecular Biology has a strong group of investigators who are using a range of experimental and computational methods to decipher the underlying physical and chemical mechanisms of macromolecular function.
Adams, Erin - Associate ProfessorStructure and biochemistry of proteins involved in immunological recognition. Characterization of gamma delta T cell receptors and their ligands and activating and inhibitory receptors involved in the innate immune response.
Arac-Ozkan, Demet - Assistant ProfessorStructural, biochemical and functional studies of adhesion proteins on the cell membrane. Understanding how adhesion-type G-protein-coupled receptors function in the brain.
Crosson, Sean - Associate ProfessorDeciphering the Structure, Function, and Topology of Microbial Signaling Systems
Greene, Geoffrey - ProfessorSteroid hormone regulation of gene networks in reproductive tissues and cancers. Structure and function of nuclear receptors.
Keenan, Robert - Associate ProfessorStructural biology and directed evolution.
Kent, Stephen - ProfessorChemical protein synthesis. Application of chemistry to the study of proteins. Mechanism of enzyme catalysis.
Koide, Shohei - ProfessorProtein design. Protein-protein interaction. Signaling network. Epigenetics. Structural biology. Synthetic biology.
Kossiakoff, Anthony - ProfessorStructure and function of hormone-receptor interactions, enzyme-inhibitor interfaces, and synthetic proteins.
Makinen, Marvin - ProfessorElectron magnetic resonance; enzyme mechanisms; metalloenzymes; molecular dynamics; structural basis of enzyme action.
Moffat, Keith - ProfessorTime-resolved macromolecular crystallography; photoreceptors; design and engineering of light-sensitive proteins
Perozo, Eduardo - ProfessorStructure and Dynamics of Ion Channels and transporters
Rice, Phoebe - ProfessorWe study mechanisms of DNA recombination and protein-DNA recognition, combining the tools of biochemistry and x-ray crystallography.
Roux, Benoit - ProfessorTheoretical and computational studies of the structure, dynamics and function of biological macromolecular systems.
Ruthenburg, Alexander - Assistant ProfessorChromatin Biochemistry, Biophysics and Chemical Biology
Sosnick, Tobin - ProfessorProtein and RNA/ribozyme folding; design of light-sensitive allosteric proteins; structure prediction, biological dynamics and thermodynamics as basis for understanding function.