Research Summary / Selected Publications
Cells regulate actin filament assembly to drive a wide range of fundamental cellular processes such as division and motility. The focus of our research group is to determine the biochemical mechanisms that govern how cells coordinate actin assembly. We utilize interdisciplinary approaches in and out of live cells including genetics, fluorescence microscopy, biochemistry, biophysics and innovative single actin filament imaging assays.
Skau, C.T., Courson, D.S., Bestul, A.J., Winkelman, J.D., Rock, R.S., Sirotkin, V., and D.R. Kovar. 2011. Actin filament bundling by fimbrin is important for endocytosis, cytokinesis and polarization in fission yeast. J. Biol. Chem. 286, 26964-77.